Gestational trophoblastic neoplasia (GTN) includes several rare malignant diseases occurring after pregnancy: invasive moles, choriocarcinoma, placental site trophoblastic tumours, and epithelioid trophoblastic tumours. Multidisciplinary protocols including multi-agent chemotherapy, surgery, and occasionally radiotherapy achieve good outcomes for some high-risk metastatic patients. In this narrative review of the published studies on the topic, we have tried to identify the role of radiotherapy. The available studies are mainly small, old, and retrospective, with incomplete data regarding radiotherapy protocols delivering low doses (which can make this disease appear radioresistant in some cases despite high response rates with palliative doses) to wide fields (whole-brain, whole-liver, etc.), which can increase toxicity. Studies considering modern techniques are needed to overcome these limitations and determine the full potential of radiotherapy beyond its antihemorrhagic and palliative roles.
妊娠滋养细胞肿瘤（GTN）包括妊娠后发生的几种罕见恶性疾病：侵袭性葡萄胎、绒毛膜癌、胎盘部位滋养细胞肿瘤和上皮样滋养细胞肿瘤。对于部分高危转移患者，采用多学科治疗方案（包括多药联合化疗、手术及偶尔的放疗）可获得良好疗效。本文通过对该领域已发表研究进行叙述性综述，尝试明确放疗在其中的作用。现有研究多为样本量小、年代较早的回顾性研究，且关于放疗方案的数据记录不完整——这些方案常采用大范围照射（全脑、全肝等）并施以低剂量（尽管姑息剂量可获得较高缓解率，但在某些情况下可能使该疾病表现出放射抵抗性），可能增加治疗毒性。需要开展采用现代放疗技术的研究来突破这些局限，从而全面评估放疗超越止血与姑息功能的潜在价值。
Radiation Therapy for Gestational Trophoblastic Neoplasia: Forward-Looking Lessons Learnt
肿瘤(癌症)患者之家