Oral submucous fibrosis (OSF) stands as a progressive oral ailment, designated as a potentially malignant disorder. OSF has gained widespread recognition as a significant precursor to malignant transformation. In the pursuit of dependable, straightforward, and non-invasive diagnostic measures for the early detection of oral malignant progression, research has delved into potential diagnostic biomarkers of OSF. This comprehensive review delves into current investigations that explore the correlation between various biomarkers and OSF. The molecular biomarkers of OSF are categorized based on cytology and sampling methods. Moreover, this review encompasses pertinent studies detailing how these biomarkers are acquired and processed. Within this scope, we scrutinize four potential biomarkers that hold the promise of facilitating the development of diagnostic tools for detecting early-stage OSF.
口腔黏膜下纤维化（OSF）是一种进行性口腔疾病，被归类为潜在恶性病变。该病症已被广泛认定为恶性转化的重要前兆。为寻求可靠、简便且无创的早期诊断方法以监测口腔恶性进展，学界针对OSF的潜在诊断生物标志物展开了深入研究。本综述系统探讨了当前关于各类生物标志物与OSF相关性的研究进展，依据细胞学特征及采样方法对OSF分子标志物进行分类，并整合了关于这些标志物获取与处理技术的相关研究。在此框架下，我们重点分析了四种具有潜力的生物标志物，这些标志物有望推动早期OSF诊断工具的研发。
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