文章：

非编码RNA在骨髓增生异常肿瘤中的作用

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

原文发布日期：30 September 2023

DOI: 10.3390/cancers15194810

类型: Article

开放获取: 是

英文摘要：

Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia, and increased risk of evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs, serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review presents a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.

摘要翻译： 

骨髓增生异常综合征或肿瘤（MDS）是一组异质性的髓系克隆性疾病，其特征包括外周血细胞减少、血液和骨髓细胞发育异常，以及向急性髓系白血病（AML）转化的风险增加。非编码RNA，特别是微小RNA和长链非编码RNA，作为正常和恶性造血过程的调控因子，在肿瘤发生中发挥重要作用。本综述全面总结了非编码RNA的生物学功能及其作用，包括研究较少的环状RNA、小干扰RNA、Piwi相互作用RNA以及核仁小RNA，探讨它们作为MDS潜在预后和/或预测性生物标志物或治疗靶点的可能性。

原文链接：

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms