The aim of this study was to investigate changes in sexuality and sexual dysfunction in head and neck cancer (HNC) patients in the first two years after treatment, in relation to the type of treatment. Data were used of 588 HNC patients participating in the prospective NETherlands Quality of life and Biomedical Cohort Study (NET-QUBIC) from diagnosis to 3, 6, 12 and 24 months after treatment. Primary outcome measures were the International Index of Erectile Function (IIEF) and the Female Sexual Function Index (FSFI). The total scores of the IIEF and FSFI were dichotomized into sexual (dys)function. In men, type of treatment was significantly associated with change in erectile function, orgasm, satisfaction with intercourse, and overall satisfaction. In women, type of treatment was significantly associated with change in desire, arousal, and orgasm. There were significant differences between treatment groups in change in dysfunctional sexuality. A deterioration in sexuality and sexual dysfunction from baseline to 3 months after treatment was observed especially in patients treated with chemoradiation. Changes in sexuality and sexual dysfunction in HNC patients were related to treatment, with an acute negative effect of chemoradiation. This effect on the various domains of sexuality seems to differ between men and women.
本研究旨在探讨头颈癌患者治疗后前两年内性功能及性功能障碍的变化与治疗方式的关系。数据来源于参与前瞻性荷兰生活质量与生物医学队列研究的588例头颈癌患者，收集时间点包括确诊时及治疗后3、6、12和24个月。主要结局指标采用国际勃起功能指数和女性性功能指数量表进行评估，将总分二分为性功能正常/功能障碍。结果显示，男性患者的治疗方式与勃起功能、性高潮、性交满意度及整体满意度变化显著相关；女性患者的治疗方式则与性欲、性唤起及性高潮变化显著相关。不同治疗组间在性功能障碍变化方面存在显著差异。特别在接受放化疗治疗的患者中，观察到从基线至治疗后3个月期间性功能及性功能障碍出现恶化。头颈癌患者的性功能及性功能障碍变化与治疗方式相关，其中放化疗具有急性负面影响，且这种影响在男女性不同性功能维度上呈现差异。
肿瘤(癌症)患者之家