文章：

食管及胃食管结合部腺癌新辅助治疗的演变历程

The Evolution of Neo-Adjuvant Therapy in the Treatment of Oesophageal and Gastro-Oesophageal Junction Adenocarcinomas

原文发布日期：27 September 2023

DOI: 10.3390/cancers15194741

类型: Article

开放获取: 是

英文摘要：

Historically, oesophageal and gastro-oesophageal junction adenocarcinomas were associated with a poor prognosis. The advent of neoadjuvant therapy has transformed the management of oesophageal and gastro-oesophageal junction adenocarcinomas further and offers the possibility to reverse disease progression, eliminate micrometastasis, and offer potentially better outcomes for these patients. This review provides an overview of landmark clinical trials in this area, with different treatment regimens considered over the years as well as potential therapeutic agents on the horizon that may transform the management of oesophageal and gastro-oesophageal junction adenocarcinomas further.

摘要翻译： 

历史上，食管及胃食管结合部腺癌的预后较差。新辅助疗法的出现进一步改变了食管及胃食管结合部腺癌的治疗模式，为逆转疾病进展、清除微转移灶提供了可能，也为患者带来了更好的治疗前景。本综述概述了该领域的里程碑式临床试验，梳理了多年来采用的不同治疗方案，并展望了可能进一步改变食管及胃食管结合部腺癌治疗格局的潜在治疗药物。

原文链接：

The Evolution of Neo-Adjuvant Therapy in the Treatment of Oesophageal and Gastro-Oesophageal Junction Adenocarcinomas