MicroRNA (miRNA) are small noncoding RNAs that play vital roles in post-transcriptional gene regulation by inhibiting mRNA translation or promoting mRNA degradation. The dysregulation of miRNA has been implicated in numerous human diseases, including cancers. miR-34 family members (miR-34s), including miR-34a, miR-34b, and miR-34c, have emerged as the most extensively studied tumor-suppressive miRNAs. In this comprehensive review, we aim to provide an overview of the major signaling pathways and gene networks regulated by miR-34s in various cancers and highlight the critical tumor suppressor role of miR-34s. Furthermore, we will discuss the potential of using miR-34 mimics as a novel therapeutic approach against cancer, while also addressing the challenges associated with their development and delivery. It is anticipated that gaining a deeper understanding of the functions and mechanisms of miR-34s in cancer will greatly contribute to the development of effective miR-34-based cancer therapeutics.
MicroRNA（miRNA）是一类小型非编码RNA，通过抑制mRNA翻译或促进mRNA降解，在转录后基因调控中发挥关键作用。miRNA的失调与多种人类疾病（包括癌症）密切相关。miR-34家族成员（包括miR-34a、miR-34b和miR-34c）已成为目前研究最广泛的肿瘤抑制性miRNA。本综述旨在系统阐述miR-34s在不同癌症中调控的主要信号通路与基因网络，并重点探讨其关键的肿瘤抑制功能。此外，我们将讨论使用miR-34模拟物作为新型癌症治疗策略的潜力，同时分析其开发与递送过程中面临的挑战。深入理解miR-34s在癌症中的功能与作用机制，将有力推动基于miR-34的有效癌症治疗方案的开发。
MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic Potential
肿瘤(癌症)患者之家