文章：

斑马鱼在肺癌研究中的应用

Zebrafish in Lung Cancer Research

原文发布日期：26 September 2023

DOI: 10.3390/cancers15194721

类型: Article

开放获取: 是

英文摘要：

Zebrafish is increasingly used as a model organism for cancer research because of its genetic and physiological similarities to humans. Modeling lung cancer (LC) in zebrafish has received significant attention. This review focuses on the insights gained from using zebrafish in LC research. These insights range from investigating the genetic and molecular mechanisms that contribute to the development and progression of LC to identifying potential drug targets, testing the efficacy and toxicity of new therapies, and applying zebrafish for personalized medicine studies. This review provides a comprehensive overview of the current state of LC research performed using zebrafish, highlights the advantages and limitations of this model organism, and discusses future directions in the field.

摘要翻译： 

斑马鱼因其与人类在遗传和生理上的相似性，正日益成为癌症研究的重要模式生物。其中，斑马鱼肺癌模型的研究备受关注。本综述聚焦于利用斑马鱼开展肺癌研究所取得的进展，涵盖从探究肺癌发生发展的遗传与分子机制，到识别潜在药物靶点、测试新疗法的疗效与毒性，以及应用于个体化医疗研究等多个方面。本文系统综述了当前基于斑马鱼的肺癌研究现状，阐述了该模型生物的优势与局限，并对该领域的未来发展方向进行了探讨。

原文链接：

Zebrafish in Lung Cancer Research