Background:Lifestyle interventions for breast cancer survivors have proved effective at stimulating positive behavior change and promoting healthy weight loss, although integrating these programs into clinical practice is challenging. We evaluated the effect of a 6-month, unsupervised, self-guided, lifestyle intervention using printed materials and online videos vs. waitlist group on body weight for breast cancer survivors.Methods:The Lifestyle, Exercise and Nutrition (LEAN) Self-Guided trial randomized breast cancer survivors with a body mass index ≥25 kg/m2to a 6-month lifestyle intervention (N = 102) or waitlist group (N = 103). Effects of the intervention on self-reported body weight, physical activity (PA), diet quality (via Health Eating Index—2010 (HEI-2010)), and quality of life were assessed using mixed model repeated measures analysis.Results:At 6 months, the intervention arm had significantly greater weight loss compared with the waitlist group (mean difference = −1.3 kg, 95% confidence interval [CI] = −2.5, −0.13). We observed suggestive improvements in PA (mean difference = 18.7 min/week, 95% CI = −24.2, 61.6), diet quality (mean difference in HEI = 3.2 points, 95% CI = −0.20, 6.5), and fatigue (mean difference in Functional Assessment of Chronic Illness Therapy—Fatigue scale = 1.4 points, 95% CI = −1.1, 3.9).Conclusions:The LEAN Self-Guided intervention led to favorable weight changes over 6 months. Low-resource-intensive programs have the potential to be delivered in diverse healthcare settings and may support breast cancer survivors in achieving a healthy body weight.
背景：生活方式干预对乳腺癌幸存者已被证实能有效促进积极行为改变并推动健康减重，但将这些项目整合到临床实践中仍具挑战性。本研究评估了为期6个月、基于印刷材料和在线视频的无监督自主指导生活方式干预与等待对照组相比，对乳腺癌幸存者体重的影响。 方法：生活方式、运动与营养（LEAN）自主指导试验将体重指数≥25 kg/m²的乳腺癌幸存者随机分配至6个月生活方式干预组（N=102）或等待对照组（N=103）。通过混合模型重复测量分析评估干预对自我报告体重、体力活动、饮食质量（采用健康饮食指数-2010）及生活质量的影响。 结果：干预6个月后，干预组体重减轻幅度显著大于对照组（平均差值=-1.3 kg，95%置信区间[-2.5, -0.13]）。在体力活动（平均差值=18.7分钟/周，95% CI[-24.2, 61.6]）、饮食质量（HEI平均差值=3.2分，95% CI[-0.20, 6.5]）及疲劳程度（慢性病治疗功能评估-疲劳量表平均差值=1.4分，95% CI[-1.1, 3.9]）方面观察到改善趋势。 结论：LEAN自主指导干预在6个月内产生了积极的体重变化。这种低资源消耗的干预模式具备在不同医疗场景中实施的潜力，可能有助于乳腺癌幸存者实现健康体重目标。
肿瘤(癌症)患者之家