Background: maxillary bone invasion (MBI) is not uncommon in hard palate or upper alveolus (HP/UA) cancer; however, there have been relatively few reports about the MBI of HP/UA cancer. Patients and Methods: this was a multi-center retrospective study, enrolling 144 cases of HP/UA cancer. MBI was defined by surgical pathology or radiology follow-up. The multiple prediction models for MBI were developed in total cases and in cases having primary bone resection, using clinical and radiological variables. Results: computerized tomography (CT) alone predicted MBI, with an area under receiver operating curve (AUC) of 0.779 (95% confidence interval (CI) = 0.712–0.847). The AUC was increased in a model that combined tumor dimensions and clinical factors (male sex and nodal metastasis) (0.854 (95%CI = 0.790–0.918)). In patients who underwent18fluorodeoxyglucose positron emission tomography/CT (PET/CT), the discrimination performance of a model including the maximal standardized uptake value (SUVmax) had an AUC of 0.911 (95%CI = 0.847–0.975). The scoring system using CT finding, tumor dimension, and clinical factors, with/without PET/CT SUVmax clearly distinguished low-, intermediate-, and high-risk groups for MBI. Conclusion: using information from CT, tumor dimension, clinical factors, and the SUVmax value, the MBI of HP/UA cancer can be predicted with a relatively high discrimination performance.
背景：上颌骨侵犯（MBI）在硬腭或上牙槽（HP/UA）癌中并不少见，但关于HP/UA癌MBI的报道相对较少。患者与方法：本研究为一项多中心回顾性研究，纳入144例HP/UA癌患者。MBI通过手术病理学或影像学随访进行定义。利用临床和影像学变量，在总体病例及接受原发性骨切除的病例中分别构建了多个MBI预测模型。结果：单独使用计算机断层扫描（CT）预测MBI的受试者工作特征曲线下面积（AUC）为0.779（95%置信区间（CI）= 0.712–0.847）。在结合肿瘤尺寸与临床因素（男性性别和淋巴结转移）的模型中，AUC提高至0.854（95%CI = 0.790–0.918）。在接受¹⁸氟脱氧葡萄糖正电子发射断层扫描/CT（PET/CT）检查的患者中，包含最大标准化摄取值（SUVmax）的模型区分性能最佳，AUC达0.911（95%CI = 0.847–0.975）。采用CT表现、肿瘤尺寸和临床因素（无论是否包含PET/CT SUVmax）构建的评分系统，能清晰区分MBI的低危、中危和高危人群。结论：综合CT信息、肿瘤尺寸、临床因素及SUVmax值，可对HP/UA癌的MBI实现具有较高区分效能的预测。
肿瘤(癌症)患者之家