Surgery with adjuvant chemoradiotherapy or chemoradiotherapy is the mainstay in treatment for advanced stage head and neck squamous cell carcinoma; however, locoregional recurrences are frequent. Salvage surgery could be proposed in selected patients to improve local control, disease-free, and overall survival. Factors for improved disease-free and overall survival in patients treated with salvage surgery include age, tumor location, the initial T stage, HPV status, resection margins, and the time elapsing from the initial treatment. Clinical trials with adjuvant therapies have shown promise after salvage surgery in terms of tolerance and response, but clinical guidelines for using these adjuvant treatments are currently lacking. The aim of this review is to present current knowledge concerning the incidence and management of recurrent head and neck squamous cell carcinoma and current data concerning survival and morbidity after salvage surgery.
手术联合辅助放化疗或单纯放化疗是晚期头颈部鳞状细胞癌的主要治疗手段，但局部区域复发仍较为常见。对于经过筛选的患者，挽救性手术可被用于改善局部控制率、无病生存期及总生存期。影响挽救性手术患者无病生存期和总生存期的因素包括年龄、肿瘤位置、初始T分期、HPV状态、手术切缘以及从初始治疗到复发的时间间隔。辅助治疗在挽救性手术后的临床试验已显示出良好的耐受性和疗效前景，但目前尚缺乏使用这些辅助治疗的临床指南。本综述旨在阐述当前关于复发性头颈部鳞状细胞癌的发病率及治疗策略，以及挽救性手术后生存率和并发症的最新数据。
Review of Outcomes after Salvage Surgery for Recurrent Squamous Cell Carcinoma of the Head and Neck
肿瘤(癌症)患者之家