文章：

乳腺癌中的雌激素受体信号传导

Estrogen Receptor Signaling in Breast Cancer

原文发布日期：23 September 2023

DOI: 10.3390/cancers15194689

类型: Article

开放获取: 是

英文摘要：

Estrogen receptor (ER) signaling is a critical regulator of cell proliferation, differentiation, and survival in breast cancer (BC) and other hormone-sensitive cancers. In this review, we explore the mechanism of ER-dependent downstream signaling in BC and the role of estrogens as growth factors necessary for cancer invasion and dissemination. The significance of the clinical implications of ER signaling in BC, including the potential of endocrine therapies that target estrogens’ synthesis and ER-dependent signal transmission, such as aromatase inhibitors or selective estrogen receptor modulators, is discussed. As a consequence, the challenges associated with the resistance to these therapies resulting from acquired ER mutations and potential strategies to overcome them are the critical point for the new treatment strategies’ development.

摘要翻译： 

雌激素受体（ER）信号通路是乳腺癌及其他激素敏感性癌症中细胞增殖、分化和存活的关键调节因子。本综述探讨了乳腺癌中ER依赖性下游信号传导的机制，以及雌激素作为癌症侵袭和扩散所必需生长因子的作用。文中讨论了ER信号通路在乳腺癌中的临床意义，包括针对雌激素合成和ER依赖性信号传导的内分泌治疗（如芳香化酶抑制剂或选择性雌激素受体调节剂）的潜力。因此，由获得性ER突变引起的治疗耐药性相关挑战及其潜在克服策略，已成为开发新型治疗策略的关键所在。

原文链接：

Estrogen Receptor Signaling in Breast Cancer