Taking into account the huge epidemiologic impact of lung cancer (in 2020, lung cancer accounted for 2,206,771 of the cases and for 1,796,144 of the cancer-related deaths, representing the second most common cancer in female patients, the most common cancer in male patients, and the second most common cancer in male and female patients) and the current lack of recommendations in terms of prognostic factors for patients selection and management, this article aims to provide an overview of the current landscape in terms of currently available immunotherapy treatments and the most promising assessed prognostic biomarkers, highlighting the current state-of-the-art and hinting at future challenges.
考虑到肺癌的巨大流行病学影响(2020年,肺癌病例数达2,206,771例,癌症相关死亡数达1,796,144例,是女性患者中第二常见的癌症、男性患者中最常见的癌症,以及男女患者合计第二常见的癌症),以及目前在患者选择和管理预后因素方面缺乏相关建议,本文旨在概述当前可用的免疫治疗方法及最具前景的评估预后生物标志物,突出当前最新进展并展望未来挑战。
Prognostic Factors in Advanced Non-Small Cell Lung Cancer Patients Treated with Immunotherapy