文章：

癸酸通过靶向肝细胞癌模型中的c-Met信号级联发挥抗肿瘤作用

Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model

原文发布日期：22 September 2023

DOI: 10.3390/cancers15194681

类型: Article

开放获取: 是

英文摘要：

DA, one of the medium-chain fatty acids found in coconut oil, is suggested to have diverse biochemical functions. However, its possible role as a chemoprevention agent in HCC has not been deciphered. Aberrant activation of c-Met can modulate tumor growth and progression in HCC. Here, we report that DA exhibited pro-found anti-tumor effects on human HCC through the suppression of HGF/c-Met signaling cascades in vitro and in vivo. It was noted that DA inhibited HGF-induced activation of c-Met and its downstream signals. DA induced apoptotic cell death and inhibited the expression of diverse tumorigenic proteins. In addition, DA attenuated tumor growth and lung metastasis in the HCC mouse model. Similar to in vitro studies, DA also suppressed the expression of c-Met and its downstream signals in mice tissues. These results highlight the substantial potential of DA in the prevention and treatment of HCC.

摘要翻译： 

癸酸作为椰子油中的一种中链脂肪酸，被认为具有多种生物化学功能。然而，其在肝细胞癌中作为化学预防剂的潜在作用尚未明确。c-Met的异常激活可调控肝细胞癌的肿瘤生长与进展。本研究发现，癸酸在体外和体内实验中通过抑制HGF/c-Met信号级联反应，对人肝细胞癌展现出显著的抗肿瘤效应。研究显示，癸酸能抑制HGF诱导的c-Met及其下游信号通路的激活，诱导肿瘤细胞凋亡，并抑制多种致瘤蛋白的表达。此外，在肝细胞癌小鼠模型中，癸酸能有效抑制肿瘤生长和肺转移。与体外实验结果一致，癸酸在小鼠组织中同样抑制了c-Met及其下游信号的表达。这些研究结果凸显了癸酸在肝细胞癌预防和治疗中的重要潜力。

原文链接：

Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model