Patients with meningiomas may have reduced health-related quality of life (HRQoL) due to postoperative neurological deficits, cognitive dysfunction, and psychosocial burden. Although advances in surgery and radiotherapy have improved progression-free survival rates, there is limited evidence regarding treatment outcomes on HRQoL. This review examines HRQoL outcomes based on tumor location and treatment modality. A systematic search in PubMed yielded 28 studies with 3167 patients. The mean age was 54.27 years and most patients were female (70.8%). Approximately 78% of meningiomas were located in the skull base (10.8% anterior, 23.3% middle, and 39.7% posterior fossae). Treatment modalities included craniotomy (73.6%), radiotherapy (11.4%), and endoscopic endonasal approach (EEA) (4.0%). The Karnofsky Performance Scale (KPS) was the most commonly utilized HRQoL instrument (27%). Preoperative KPS scores > 80 were associated with increased occurrence of postoperative neurological deficits. A significant difference was found between pre- and post-operative KPS scores for anterior/middle skull base meningiomas (SBMs) in comparison to posterior (SBMs) when treated with craniotomy. Post-craniotomy SF-36 scores were lower for posterior SBMs in comparison to those in the anterior and middle fossae. Risk factors for poor neurological outcomes include a high preoperative KPS score and patients with posterior SBMs may experience a greater burden in HRQoL.
脑膜瘤患者可能因术后神经功能缺损、认知功能障碍及心理社会负担而导致健康相关生活质量下降。尽管手术与放射治疗技术的进步已提高了无进展生存率，但关于治疗对生活质量影响的证据仍有限。本综述基于肿瘤位置和治疗方式对生活质量结局进行系统分析。通过PubMed数据库检索获得28项研究，共纳入3167例患者，平均年龄54.27岁，女性占70.8%。约78%的脑膜瘤位于颅底（前颅窝10.8%，中颅窝23.3%，后颅窝39.7%）。治疗方式包括开颅手术（73.6%）、放射治疗（11.4%）和内镜经鼻入路手术（4.0%）。卡氏功能状态评分量表是最常用的生活质量评估工具（27%）。术前卡氏评分高于80分与术后神经功能缺损发生率增加相关。开颅治疗的前/中颅窝脑膜瘤与后颅窝脑膜瘤相比，术前术后卡氏评分存在显著差异。后颅窝脑膜瘤患者开颅术后的简明健康调查量表评分低于前、中颅窝患者。神经功能预后不良的危险因素包括高术前卡氏评分，而后颅窝脑膜瘤患者可能承受更严重的生活质量负担。
肿瘤(癌症)患者之家