文章：

预测老年化疗患者严重毒性与早期死亡风险

Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients Treated with Chemotherapy

原文发布日期：21 September 2023

DOI: 10.3390/cancers15184670

类型: Article

开放获取: 是

英文摘要：

Background: Determining the risk of grade 3–5 toxicity and early death (ED) is important to plan chemotherapy in older adult patients with cancer. Our objective was to identify factors predicting these complications at the time of treatment initiation. Methods: 234 patients aged ≥70 were subjected to a geriatric assessment and variables related to the tumor and the treatment were also collected. Logistic regression multivariable analysis was used to relate these factors with the appearance of grade 3–5 toxicity and ED. Predictive scores for both toxicity and ED were then developed. Results: Factors related to grade 3–5 toxicity were hemoglobin, MAX2 index, ADL, and the CONUT score. Factors related to ED were tumor stage and the GNRI score. Two predictive scores were developed using these variables. ROC curves for the prediction of toxicity and ED were 0.71 (95% CI: 0.64–0.78) and 0.73 (95% CI: 0.68–0.79), respectively. Conclusions: Two simple and reliable scores were developed to predict grade 3–5 toxicity and ED in older adult patients with cancer. This may be helpful in treatment planning.

摘要翻译： 

背景：评估老年癌症患者发生3-5级毒性和早期死亡（ED）的风险对于制定化疗方案至关重要。本研究旨在识别治疗开始时能够预测这些并发症的相关因素。方法：对234名年龄≥70岁的患者进行老年综合评估，同时收集肿瘤及治疗相关变量。采用多变量逻辑回归分析这些因素与3-5级毒性及ED发生的关系，并据此构建毒性及ED的预测评分模型。结果：与3-5级毒性相关的因素包括血红蛋白水平、MAX2指数、日常生活活动能力（ADL）及营养控制状态（CONUT）评分；与ED相关的因素为肿瘤分期及老年营养风险指数（GNRI）评分。基于这些变量构建的两个预测评分模型，其预测毒性及ED的受试者工作特征曲线下面积分别为0.71（95% CI: 0.64–0.78）和0.73（95% CI: 0.68–0.79）。结论：本研究构建了两种简便可靠的评分模型，可用于预测老年癌症患者的3-5级毒性及ED风险，为临床治疗决策提供参考依据。

原文链接：

Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients Treated with Chemotherapy