文章：

挽救性高剂量率介入放射治疗（近距离放射治疗）联合手术用于区域复发性头颈部癌症

Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers

原文发布日期：14 September 2023

DOI: 10.3390/cancers15184549

类型: Article

开放获取: 是

英文摘要：

(1) Background: to report on the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for patients with regionally relapsed head and neck cancers. (2) Methods: A retrospective study of 60 patients treated with HDR-IRT for loco-regionally relapsed head and neck cancers at our institution (2016–2020). Treatment procedure, results, and related toxicities were collected. Local and overall survival outcomes were analyzed. (3) Results: The median follow-up was 22.4 months. Twenty-nine (48.3%) patients had locoregional recurrences with a median time of 28.9 months. The local-recurrence free-survival was 88.1% and 37.3% at 3 years and 5 years. At the last follow-up, 21 patients were alive and the median time to death was 24 months. The overall survival was 39.2% and 16.6% at 3 years and 5 years. Collectively, there were 28 events of grade ≥ 3 late toxicities recorded in 21 patients (35%). (4) Conclusions: Salvage HDR-IRT combined with surgery offers a second-line curative treatment option for regionally relapsed head and neck cancers with acceptable outcomes and toxicities.

摘要翻译： 

(1) 背景：本研究旨在报告高剂量率介入放射治疗（近距离放射治疗，IRT）作为区域性复发头颈部癌挽救性治疗的应用情况。(2) 方法：回顾性分析2016年至2020年间在本机构接受HDR-IRT治疗的60例局部区域性复发头颈部癌患者。收集治疗流程、疗效及相关毒性反应数据，并对局部控制率及总生存期进行分析。(3) 结果：中位随访时间为22.4个月。29例（48.3%）患者出现局部区域性复发，中位复发时间为28.9个月。3年及5年局部无复发生存率分别为88.1%和37.3%。末次随访时21例患者存活，中位死亡时间为24个月。3年及5年总生存率分别为39.2%和16.6%。共记录到21例患者（35%）发生28次≥3级晚期毒性反应。(4) 结论：挽救性HDR-IRT联合手术为区域性复发头颈部癌患者提供了具有可接受疗效及毒性的二线根治性治疗方案。

原文链接：

Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers