文章：

电子烟使用、环境毒物暴露与肺癌风险

Vaping, Environmental Toxicants Exposure, and Lung Cancer Risk

原文发布日期：12 September 2023

DOI: 10.3390/cancers15184525

类型: Article

开放获取: 是

英文摘要：

Lung cancer (LC) is the second-most prevalent tumor worldwide. According to the most recent GLOBOCAN data, over 2.2 million LC cases were reported in 2020, with an estimated new death incident of 1,796,144 lung cancer cases. Genetic, lifestyle, and environmental exposure play an important role as risk factors for LC. E-cigarette, or vaping, products (EVPs) use has been dramatically increasing world-wide. There is growing concern that EVPs consumption may increase the risk of LC because EVPs contain several proven carcinogenic compounds. However, the relationship between EVPs and LC is not well established. E-cigarette contains nicotine derivatives (e.g., nitrosnornicotine, nitrosamine ketone), heavy metals (including organometal compounds), polycyclic aromatic hydrocarbons, and flavorings (aldehydes and complex organics). Several environmental toxicants have been proven to contribute to LC. Proven and plausible environmental carcinogens could be physical (ionizing and non-ionizing radiation), chemicals (such as asbestos, formaldehyde, and dioxins), and heavy metals (such as cobalt, arsenic, cadmium, chromium, and nickel). Air pollution, especially particulate matter (PM) emitted from vehicles and industrial exhausts, is linked with LC. Although extensive environmental exposure prevention policies and smoking reduction strategies have been adopted globally, the dangers remain. Combined, both EVPs and toxic environmental exposures may demonstrate significant synergistic oncogenicity. This review aims to analyze the current publications on the importance of the relationship between EVPs consumption and environmental toxicants in the pathogenesis of LC.

摘要翻译： 

肺癌是全球范围内发病率第二高的恶性肿瘤。根据最新的GLOBOCAN数据，2020年报告肺癌病例超过220万例，估计新增死亡病例达1,796,144例。遗传因素、生活方式及环境暴露是肺癌的重要风险因素。电子烟产品在全球范围内的使用率急剧上升。由于电子烟含有多种已确认的致癌化合物，人们日益担忧其使用可能增加肺癌风险，但两者间的关联尚未明确。电子烟含有尼古丁衍生物（如亚硝基去甲烟碱、亚硝胺酮）、重金属（包括有机金属化合物）、多环芳烃及调味剂（醛类及复杂有机物）。多种环境毒物已被证实可导致肺癌发生，已确认及潜在的环境致癌物包括物理因素（电离与非电离辐射）、化学物质（如石棉、甲醛、二噁英）以及重金属（如钴、砷、镉、铬、镍）。空气污染，特别是机动车和工业排放的颗粒物，与肺癌发病密切相关。尽管全球已广泛实施环境暴露预防政策和控烟策略，相关风险依然存在。电子烟与环境毒物暴露可能产生显著的协同致癌效应。本文旨在通过分析现有文献，探讨电子烟使用与环境毒物在肺癌发病机制中的关联性及其重要意义。

原文链接：

Vaping, Environmental Toxicants Exposure, and Lung Cancer Risk