文章：

现代背景下的时间验证策略：化疗在结直肠癌治疗中持续重要性的文献计量学研究

Time-Tested Strategies in Modern Context: A Bibliometric Study of Chemotherapy’s Continued Importance in Colorectal Cancer Treatment

原文发布日期：12 September 2023

DOI: 10.3390/cancers15184520

类型: Article

开放获取: 是

英文摘要：

In the landscape of colorectal cancer treatment, classical chemotherapeutic agents such as 5-fluorouracil, capecitabine, irinotecan, oxaliplatin, trifluridine, and tipiracil have historically played a pivotal role. This study presents a comprehensive bibliometric analysis of the top 100 most influential articles focusing on these classic chemotherapy drugs in the management of colorectal cancer. With this, we shed light on their current importance, despite the emergence of new therapeutic targets and treatments in the field of oncology. Systematically evaluating research outputs, this analysis reveals a prevalence of co-authorship among institutions, countries (led by the United States, China, and Europe), and researchers highlighting the global and collaborative nature of efforts in research, utilization, and development of these drugs. Three thematic axes lead the research: pharmacogenetics, the development of new pharmaceutical forms, and the use of adjuvants. This research serves as a foundation for future endeavors, aiding researchers, clinicians, and policymakers in making informed decisions about the direction of research and development in the dynamic field of colorectal cancer therapy.

摘要翻译： 

在结直肠癌治疗领域，5-氟尿嘧啶、卡培他滨、伊立替康、奥沙利铂、曲氟尿苷及替吡嘧啶等经典化疗药物历来发挥着关键作用。本研究针对结直肠癌治疗中这些经典化疗药物领域最具影响力的百篇文献进行了系统的文献计量学分析。通过此项研究，我们揭示了这些药物在肿瘤学领域不断涌现新治疗靶点和疗法的背景下，仍保持重要地位的现实意义。系统评估研究产出后发现，机构间、国家间（以美国、中国和欧洲为主导）及研究者间的合作著述现象普遍存在，凸显了这些药物在研究、应用与开发过程中全球协作的本质特征。当前研究主要围绕三大主题展开：药物遗传学、新型药物剂型开发以及辅助用药策略。本研究为未来工作奠定了基础，有助于研究人员、临床医生和政策制定者在动态发展的结直肠癌治疗领域中，就研发方向做出科学决策。

原文链接：

Time-Tested Strategies in Modern Context: A Bibliometric Study of Chemotherapy’s Continued Importance in Colorectal Cancer Treatment