This case-control study investigates the associations between head and neck cancer (HNC), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection. We included 5603 patients who had received a diagnosis of HNC as cases and 16,809 propensity score matching controls. We employed multivariate logistic regression models to evaluate the association of HNC with HBV and HCV infection after taking sociodemographic characteristics and diabetes, hypertension, hyperlipidemia, HPV infection, tobacco use disorder, and alcohol abuse/alcohol dependence syndrome into considerations. Results show that 7.9% of the total sample had been previously diagnosed with HBV infection, with 9.0% prevalence among cases and 7.6% among controls (p< 0.001). The chi-squared test suggests a significant difference in the prevalence of HCV infection between cases and controls (3.3% vs. 2.7%,p= 0.019). The covariate-adjusted odds ratio (OR) of HBV infection in patients with HNC relative to controls was 1.219 (95% CI = 1.093~1.359). Additionally, the adjusted OR of HCV infection in patients with HNC was 1.221 (95% CI = 1.023~1.457) compared to controls. Furthermore, patients with oropharyngeal cancer were more likely to have HCV infection than controls (adjusted OR = 2.142, 95% CI = 1.171~3.918). Our study provides evidence that suggests a potential association between HBV and HCV infections and the risk of HNC.
本病例对照研究探讨头颈癌（HNC）与乙型肝炎病毒（HBV）及丙型肝炎病毒（HCV）感染之间的关联。研究纳入5603例确诊HNC患者作为病例组，并采用倾向评分匹配法选取16809例对照。在控制社会人口学特征、糖尿病、高血压、高脂血症、HPV感染、烟草使用障碍及酒精滥用/酒精依赖综合征等因素后，通过多变量逻辑回归模型评估HNC与HBV、HCV感染的相关性。结果显示：总样本中7.9%曾有HBV感染史，病例组感染率为9.0%，对照组为7.6%（p<0.001）；卡方检验提示病例组与对照组HCV感染率存在显著差异（3.3% vs. 2.7%，p=0.019）。经协变量调整后，HNC患者感染HBV的比值比（OR）为1.219（95% CI = 1.093~1.359）；感染HCV的调整后OR值为1.221（95% CI = 1.023~1.457）。此外，口咽癌患者感染HCV的风险显著高于对照组（调整后OR = 2.142，95% CI = 1.171~3.918）。本研究为HBV和HCV感染与HNC风险之间的潜在关联提供了证据支持。
Associations of Head and Neck Cancer with Hepatitis B Virus and Hepatitis C Virus Infection
肿瘤(癌症)患者之家