文章：

多族裔儿科及成人诊所患者群体中高危口腔人乳头瘤病毒（HPV31、HPV33、HPV35）的筛查

Screening for High-Risk Oral Human Papillomavirus (HPV31, HPV33, HPV35) in a Multi-Racial Pediatric and Adult Clinic Patient Population

原文发布日期：10 September 2023

DOI: 10.3390/cancers15184501

类型: Article

开放获取: 是

英文摘要：

Many human papillomavirus (HPV) strains induce cancer in the cervix and the oral cavity. Although high-risk strains including HPV16 and HPV18 are commonly known, additional high-risk strains including HPV31, HPV33, and HPV35 may also induce carcinogenesis, and much less is known about their prevalence. Using an approved protocol, samples from a salivary biorepository were screened to find pediatric and adult samples from a multi-ethnic, university-based patient clinic population. A total ofN= 86 samples from the saliva biorepository met the quality and concentration standards and were screened for high-risk HPV. qPCR screening of adult samples revealedn= 10/45 or 22% were HPV31- or HPV33-positive. In addition, a total ofn= 9/41 or 21.9% of pediatric samples were either HPV31- or HPV33-positive (or both). No samples harbored HPV35. Most samples were derived from patients within the recommended vaccination or catch-up age range (age 9–45 years). These results demonstrated that a significant percentage of patients harbor additional high-risk HPV strains within the oral cavity, including HPV31 and HPV33. These data support oral healthcare provider recommendations for the newer nine-valent vaccine, which includes both HPV31 and HPV33.

摘要翻译： 

多种人乳头瘤病毒（HPV）毒株可诱发宫颈及口腔癌变。除已知的高危型别如HPV16和HPV18外，其他高危型别如HPV31、HPV33和HPV35同样具有致癌潜力，但其流行特征尚不明确。本研究依据经批准的实验方案，对唾液生物样本库中来自多民族大学附属门诊患者群体的儿童及成人样本进行筛查。共计86份唾液样本符合质量与浓度标准，并接受高危型HPV筛查。qPCR检测显示，成人样本中10/45例（22%）呈HPV31或HPV33阳性；儿童样本中9/41例（21.9%）呈HPV31或/和HPV33阳性。所有样本均未检出HPV35。多数样本来自建议疫苗接种或补种年龄范围（9-45岁）的患者。研究结果表明，口腔内存在相当比例的患者携带HPV31和HPV33等额外高危型HPV毒株。这些数据支持口腔健康从业者推荐涵盖HPV31和HPV33的新型九价疫苗。

原文链接：

Screening for High-Risk Oral Human Papillomavirus (HPV31, HPV33, HPV35) in a Multi-Racial Pediatric and Adult Clinic Patient Population