文章：

碳离子治疗缺氧性肿瘤：我们是否已充分利用其潜力？

Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them?

原文发布日期：9 September 2023

DOI: 10.3390/cancers15184494

类型: Article

开放获取: 是

英文摘要：

Hypoxia, which is associated with abnormal vessel growth, is a characteristic feature of many solid tumors that increases their metastatic potential and resistance to radiotherapy. Carbon-ion radiation therapy, either alone or in combination with other treatments, is one of the most promising treatments for hypoxic tumors because the oxygen enhancement ratio decreases with increasing particle LET. Nevertheless, current clinical practice does not yet fully benefit from the use of carbon ions to tackle hypoxia. Here, we provide an overview of the existing experimental and clinical evidence supporting the efficacy of C-ion radiotherapy in overcoming hypoxia-induced radioresistance, followed by a discussion of the strategies proposed to enhance it, including different approaches to maximize LET in the tumors.

摘要翻译： 

缺氧是许多实体肿瘤的典型特征，常伴随异常血管生长，这会增强肿瘤的转移潜能及对放射治疗的抵抗性。碳离子放射治疗，无论是单独使用还是与其他疗法联合，都是治疗缺氧肿瘤最具前景的方法之一，因为氧增比随粒子线性能量传递值的增加而降低。然而，目前的临床实践尚未充分利用碳离子来应对缺氧问题。本文综述了支持碳离子放疗在克服缺氧诱导的放射抵抗方面有效性的现有实验和临床证据，并进一步探讨了增强其疗效的多种策略，包括最大化肿瘤内线性能量传递值的不同方法。

原文链接：

Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them?