Patients diagnosed with breast cancer are likely to be diagnosed with thyroid cancer as a second primary cancer. Similarly, patients with thyroid cancer are likely to develop breast cancer. In this study, we found an association between these two types of cancers in the microbiomes of patients with breast cancer. Blood samples were collected from 96 patients with breast cancer, their bacterial extracellular vesicles were isolated, and their microbiomes were analyzed. After microbiome analysis, researchers performed thyroid function tests, estrogen levels, and thyroid ultrasound results of these patients, and the relationships among these parameters were analyzed. Based on the thyroid ultrasonography results, differences in the microbiome were confirmed in the normal, cyst, nodule, and thyroid lobectomy groups. We investigated the microbiome differences between normal thyroid and thyroid cancer. In particular, the abundance of the genusBacillusis related to estrogen levels, which could affect thyroid abnormalities and increase thyroid-stimulating hormone levels. This study explains the causes of thyroid cancer in patients with breast cancer using microbiomes and serological tests for thyroid hormones and estrogen. These can be used as basic data for preventing thyroid cancer in patients with breast cancer.
被诊断为乳腺癌的患者很可能被诊断出甲状腺癌作为第二原发癌。同样，甲状腺癌患者也可能罹患乳腺癌。本研究在乳腺癌患者的微生物组中发现了这两种癌症之间的关联。我们采集了96名乳腺癌患者的血液样本，分离其细菌外泌体并分析其微生物组。完成微生物组分析后，研究人员对这些患者进行了甲状腺功能检测、雌激素水平测定及甲状腺超声检查，并分析了这些参数之间的相互关系。根据甲状腺超声检查结果，我们在正常组、囊肿组、结节组和甲状腺叶切除组中确认了微生物组的差异。我们特别研究了正常甲状腺与甲状腺癌之间的微生物组差异。值得注意的是，芽孢杆菌属的丰度与雌激素水平相关，这可能影响甲状腺异常并增加促甲状腺激素水平。本研究通过微生物组分析以及甲状腺激素和雌激素的血清学检测，阐释了乳腺癌患者发生甲状腺癌的成因。这些发现可作为预防乳腺癌患者发生甲状腺癌的基础数据。
The Role of Blood Microbiome in the Development of Thyroid Cancer in Breast Cancer Survivors
肿瘤(癌症)患者之家