Soft tissue sarcomas of the extremities are rare tumors with various prognostic factors. Their management is debatable due to their inconsistent results within the literature and the lack of large prospective studies. The objective of this systematic review is to analyze the available scientific data on prognostic factors concerning the characteristics of the patients, the disease and the treatments performed, as well as their potential complications, on studies with a median follow-up of 5 years at minimum. A search of articles following the “PRISMA method” and using the PubMed search engine was conducted to select the most relevant studies. Twenty-five articles were selected, according to preestablished criteria. This review provides a better understanding of the prognosis and disease outcome of these tumors. Many factors were described comparing the frequency of occurrence according to the studies, which remain heterogeneous between them. Significant factors that could orient patients to radiotherapy were highlighted. These positive prognostic factors provide valuable insight to optimize radiotherapy treatments for patients treated for soft tissue sarcoma of the extremities.
四肢软组织肉瘤是一种罕见肿瘤，其预后影响因素复杂多样。由于现有文献报道结果不一致且缺乏大规模前瞻性研究，其临床管理策略仍存争议。本系统性综述旨在分析患者特征、疾病特点、治疗方案及其潜在并发症等预后相关因素的现有科学证据，所有纳入研究均要求至少具备5年期中位随访时间。通过遵循"PRISMA方法"并运用PubMed搜索引擎进行文献检索，最终按照预设标准筛选出25篇相关研究。本综述深化了对该类肿瘤预后及疾病转归的理解，通过对比各研究报道的发生频率，系统阐述了多种影响因素，但各研究间仍存在异质性。研究特别明确了可指导患者接受放射治疗的重要指标，这些积极的预后因素为优化四肢软组织肉瘤患者的放射治疗方案提供了有价值的参考依据。
肿瘤(癌症)患者之家