Functional magnetic resonance imaging (fMRI) with blood oxygen level-dependent (BOLD) technique is useful for preoperative mapping of brain functional networks in tumor patients, providing reliable in vivo detection of eloquent cortex to help reduce the risk of postsurgical morbidity. BOLD task-based fMRI (tb-fMRI) is the most often used noninvasive method that can reliably map cortical networks, including those associated with sensorimotor, language, and visual functions. BOLD resting-state fMRI (rs-fMRI) is emerging as a promising ancillary tool for visualization of diverse functional networks. Although fMRI is a powerful tool that can be used as an adjunct for brain tumor surgery planning, it has some constraints that should be taken into consideration for proper clinical interpretation. BOLD fMRI interpretation may be limited by neurovascular uncoupling (NVU) induced by brain tumors. Cerebrovascular reactivity (CVR) mapping obtained using breath-hold methods is an effective method for evaluating NVU potential.
基于血氧水平依赖技术的功能磁共振成像在脑肿瘤患者术前功能网络定位中具有重要价值，能够可靠地实现功能皮层的活体检测，有助于降低术后并发症风险。任务态BOLD-fMRI是目前最常用的无创性皮层网络定位方法，可准确映射感觉运动、语言及视觉等相关功能网络。静息态BOLD-fMRI作为新兴的辅助工具，在多种功能网络可视化方面展现出应用前景。尽管功能磁共振成像可作为脑肿瘤手术规划的有效辅助手段，但其临床应用需注意相关局限性。脑肿瘤可能诱发神经血管解偶联现象，这会制约BOLD-fMRI的解读准确性。通过屏气法获取脑血管反应性图谱，是评估神经血管解偶联风险的有效方法。
Detection and Mitigation of Neurovascular Uncoupling in Brain Gliomas
肿瘤(癌症)患者之家