文章：

皮肤癌中的分子分类器：挑战与前景

Molecular Classifiers in Skin Cancers: Challenges and Promises

原文发布日期：7 September 2023

DOI: 10.3390/cancers15184463

类型: Article

开放获取: 是

英文摘要：

Skin cancers are common and heterogenous malignancies affecting up to two in three Australians before age 70. Despite recent developments in diagnosis and therapeutic strategies, the mortality rate and costs associated with managing patients with skin cancers remain high. The lack of well-defined clinical and histopathological features makes their diagnosis and classification difficult in some cases and the prognostication difficult in most skin cancers. Recent advancements in large-scale “omics” studies, including genomics, transcriptomics, proteomics, metabolomics and imaging-omics, have provided invaluable information about the molecular and visual landscape of skin cancers. On many occasions, it has refined tumor classification and has improved prognostication and therapeutic stratification, leading to improved patient outcomes. Therefore, this paper reviews the recent advancements in omics approaches and appraises their limitations and potential for better classification and stratification of skin cancers.

摘要翻译： 

皮肤癌是常见且异质性的恶性肿瘤，在澳大利亚70岁以下人群中发病率高达三分之二。尽管近年来诊断和治疗策略有所进展，但皮肤癌患者的死亡率及治疗成本依然居高不下。由于缺乏明确的临床和组织病理学特征，部分病例的诊断与分类存在困难，且多数皮肤癌的预后评估具有挑战性。近年来大规模组学研究（包括基因组学、转录组学、蛋白质组学、代谢组学及影像组学）的进展，为揭示皮肤癌的分子与视觉特征提供了宝贵信息。这些技术多次优化了肿瘤分类体系，提升了预后判断与治疗分层的精准度，从而改善了患者临床结局。本文系统综述了组学方法的最新进展，并评估其在优化皮肤癌分类与分层方面的局限性与应用潜力。

原文链接：

Molecular Classifiers in Skin Cancers: Challenges and Promises