文章：

微小RNA可通过失调整合素活性影响卵巢癌进展

MicroRNAs Can Influence Ovarian Cancer Progression by Dysregulating Integrin Activity

原文发布日期：8 September 2023

DOI: 10.3390/cancers15184449

类型: Article

开放获取: 是

英文摘要：

Ovarian cancer is a deadly disease that affects thousands of women worldwide. Integrins, transmembrane receptors that mediate cell adhesion and signaling, play important roles in ovarian cancer progression, metastasis, and drug resistance. Dysregulated expression of integrins is implicated in various cellular processes, such as cell migration, invasion, and proliferation. Emerging evidence suggests that microRNAs (miRNAs) can regulate integrin expression and function, thus affecting various physiological and pathological processes, including ovarian cancer. In this article, we review the current understanding of integrin-mediated cellular processes in ovarian cancer and the roles of miRNAs in regulating integrins. We also discuss the therapeutic potential of targeting miRNAs that regulate integrins for the treatment of ovarian cancer. Targeting miRNAs that regulate integrins or downstream signaling pathways of integrins may provide novel therapeutic strategies for inhibiting integrin-mediated ovarian cancer progression.

摘要翻译： 

卵巢癌是一种影响全球成千上万女性的致命疾病。整合素作为介导细胞粘附和信号转导的跨膜受体，在卵巢癌的进展、转移和耐药性中发挥着重要作用。整合素表达失调涉及多种细胞过程，如细胞迁移、侵袭和增殖。新近证据表明，微小RNA（miRNA）能够调控整合素的表达与功能，从而影响包括卵巢癌在内的多种生理和病理过程。本文综述了目前对整合素介导的卵巢癌细胞过程的理解，以及miRNA在调控整合素中的作用。同时探讨了靶向调控整合素的miRNA在卵巢癌治疗中的潜在价值。通过靶向调控整合素或其下游信号通路的miRNA，可能为抑制整合素介导的卵巢癌进展提供新的治疗策略。

原文链接：

MicroRNAs Can Influence Ovarian Cancer Progression by Dysregulating Integrin Activity