文章：

影像组学：在胶质瘤与多形性胶质母细胞瘤中鉴别进展、复发、假性进展与放射性坏死的新前景

Radiomics: The New Promise for Differentiating Progression, Recurrence, Pseudoprogression, and Radionecrosis in Glioma and Glioblastoma Multiforme

原文发布日期：5 September 2023

DOI: 10.3390/cancers15184429

类型: Article

开放获取: 是

英文摘要：

Glioma and glioblastoma multiform (GBM) remain among the most debilitating and life-threatening brain tumors. Despite advances in diagnosing approaches, patient follow-up after treatment (surgery and chemoradiation) is still challenging for differentiation between tumor progression/recurrence, pseudoprogression, and radionecrosis. Radiomics emerges as a promising tool in initial diagnosis, grading, and survival prediction in patients with glioma and can help differentiate these post-treatment scenarios. Preliminary published studies are promising about the role of radiomics in post-treatment glioma/GBM. However, this field faces significant challenges, including a lack of evidence-based solid data, scattering publication, heterogeneity of studies, and small sample sizes. The present review explores radiomics’s capabilities in following patients with glioma/GBM status post-treatment and to differentiate tumor progression, recurrence, pseudoprogression, and radionecrosis.

摘要翻译： 

胶质瘤与多形性胶质母细胞瘤（GBM）仍属最具致残性与致命性的脑肿瘤类型。尽管诊断方法不断进步，但在治疗（手术及放化疗）后对患者进行随访时，区分肿瘤进展/复发、假性进展与放射性坏死仍面临挑战。影像组学作为新兴技术手段，在胶质瘤患者的初诊、分级及生存预测中展现出应用潜力，并有望协助鉴别上述治疗后不同状况。现有初步研究显示影像组学在胶质瘤/GBM治疗后评估中具有良好前景，但该领域仍面临重大挑战，包括缺乏循证医学坚实数据支撑、研究成果分散、研究异质性显著以及样本量有限等。本综述旨在探讨影像组学在胶质瘤/GBM患者治疗后状态监测中，区分肿瘤进展、复发、假性进展与放射性坏死的应用潜力。

原文链接：

Radiomics: The New Promise for Differentiating Progression, Recurrence, Pseudoprogression, and Radionecrosis in Glioma and Glioblastoma Multiforme