Oncofertility is any therapeutic intervention to safeguard the fertility of cancer patients. Anti-cancer therapies (chemotherapy, radiation therapy, etc.) entail the risk of reproductive disorders through cytotoxic effects on gamete-building cells, especially those not yet fully developed. This literature review analyzes the available data on securing fertility in pediatric and adolescent populations to identify the methods used and describe aspects related to financing, ethics, and the perspective of patients and their parents. Topics related to oncofertility in this age group are relatively niche, with few peer-reviewed articles available and published studies mostly on adults. Compared to pubertal individuals, a limited number of fertility preservation methods are used for prepubertal patients. Funding for the procedures described varies from country to country, but only a few governments choose to reimburse them. Oncofertility of pediatric and adolescent patients raises many controversies related to the decision, parents’ beliefs, having a partner, ethics, as well as the knowledge and experience of healthcare professionals. As the fertility of young cancer patients is at risk, healthcare professionals should make every effort to provide them with an opportunity to fulfill their future reproductive plans and to have a family and offspring. Systemic solutions should form the basis for the development of oncofertility in pediatric and adolescent populations.
肿瘤生育力保护是指为保障癌症患者生育能力而采取的任何治疗干预措施。抗癌疗法（化疗、放疗等）通过对配子形成细胞（尤其是尚未完全发育的细胞）产生细胞毒性作用，可能导致生殖功能障碍风险。本文献综述通过分析儿童及青少年群体生育力保存的现有数据，系统梳理当前采用的技术方法，并从资金支持、伦理考量、患者及其家属视角等多维度进行阐述。该年龄段的肿瘤生育力保护研究尚属相对小众领域，经同行评议的文献数量有限，现有发表成果多集中于成人群体。与青春期患者相比，针对青春期前患者的生育力保存方法选择更为有限。各国对相关医疗程序的资金支持政策存在差异，仅少数政府选择将其纳入报销范围。儿童及青少年肿瘤生育力保护涉及决策机制、父母信仰、伴侣关系、伦理规范以及医疗专业人员的知识经验等多重争议议题。鉴于年轻癌症患者的生育能力面临威胁，医疗专业人员应竭尽全力为其提供实现未来生育计划、组建家庭并养育后代的机会。建立系统性解决方案应成为推动儿童及青少年肿瘤生育力保护领域发展的基石。
肿瘤(癌症)患者之家