文章：

癌症中逆转录转座子的调控与免疫特征

The Regulation and Immune Signature of Retrotransposons in Cancer

原文发布日期：30 August 2023

DOI: 10.3390/cancers15174340

类型: Article

开放获取: 是

英文摘要：

Advances in sequencing technologies and the bioinformatic analysis of big data facilitate the study of jumping genes’ activity in the human genome in cancer from a broad perspective. Retrotransposons, which move from one genomic site to another by a copy-and-paste mechanism, are regulated by various molecular pathways that may be disrupted during tumorigenesis. Active retrotransposons can stimulate type I IFN responses. Although accumulated evidence suggests that retrotransposons can induce inflammation, the research investigating the exact mechanism of triggering these responses is ongoing. Understanding these mechanisms could improve the therapeutic management of cancer through the use of retrotransposon-induced inflammation as a tool to instigate immune responses to tumors.

摘要翻译： 

测序技术的进步与大数据的生物信息学分析，为从更广阔的视角研究癌症中人类基因组内跳跃基因的活性提供了便利。逆转录转座子通过“复制-粘贴”机制在基因组不同位点间移动，其活性受多种分子通路调控，这些通路在肿瘤发生过程中可能被破坏。活跃的逆转录转座子能够刺激I型干扰素反应。尽管已有证据表明逆转录转座子可诱发炎症，但其触发这些反应的具体机制研究仍在持续深入。理解这些机制有望通过利用逆转录转座子诱导的炎症作为激发肿瘤免疫应答的工具，从而改善癌症的治疗策略。

原文链接：

The Regulation and Immune Signature of Retrotransposons in Cancer