YY1 is widely recognized as an intrinsically disordered transcription factor that plays a role in development of many cancers. In most cases, its overexpression is correlated with tumor progression and unfavorable patient outcomes. Our latest research focusing on the role of zinc ions in modulating YY1’s interaction with DNA demonstrated that zinc enhances the protein’s multimeric state and affinity to its operator. In light of these findings, changes in protein concentration appear to be just one element relevant to modulating YY1-dependent processes. Thus, alterations in zinc ion concentration can directly and specifically impact the regulation of gene expression by YY1, in line with reports indicating a correlation between zinc ion levels and advancement of certain tumors. This review concentrates on other potential consequences of YY1 interaction with zinc ions that may act by altering charge distribution, conformational state distribution, or oligomerization to influence its interactions with molecular partners that can disrupt gene expression patterns.
YY1作为一种广泛认可的内在无序转录因子，在多种癌症的发生发展中发挥重要作用。在多数情况下，其过度表达与肿瘤进展及不良预后密切相关。我们最新关于锌离子调控YY1与DNA相互作用的研究表明，锌离子能增强该蛋白的多聚化状态及其与操纵基因的结合亲和力。基于这些发现，蛋白质浓度的变化似乎仅是调控YY1依赖性过程的因素之一。因此，锌离子浓度的改变可直接且特异性地影响YY1对基因表达的调控，这与已有研究指出的锌离子水平与特定肿瘤进展相关的报道相一致。本综述聚焦于YY1与锌离子相互作用可能产生的其他潜在影响，这些影响可能通过改变电荷分布、构象状态分布或寡聚化程度，进而影响其与分子伴侣的相互作用，最终破坏基因表达模式。
Zinc Ions Modulate YY1 Activity: Relevance in Carcinogenesis
肿瘤(癌症)患者之家