文章：

IV型P型ATP酶：在癌症发生、进展与治疗中的最新研究进展

Type IV P-Type ATPases: Recent Updates in Cancer Development, Progression, and Treatment

原文发布日期：30 August 2023

DOI: 10.3390/cancers15174327

类型: Article

开放获取: 是

英文摘要：

Adaptations of cancer cells for survival are remarkable. One of the most significant properties of cancer cells to prevent the immune system response and resist chemotherapy is the altered lipid metabolism and resulting irregular cell membrane composition. The phospholipid distribution in the plasma membrane of normal animal cells is distinctly asymmetric. Lipid flippases are a family of enzymes regulating membrane asymmetry, and the main class of flippases are type IV P-type ATPases (P4-ATPases). Alteration in the function of flippases results in changes to membrane organization. For some lipids, such as phosphatidylserine, the changes are so drastic that they are considered cancer biomarkers. This review will analyze and discuss recent publications highlighting the role that P4-ATPases play in the development and progression of various cancer types, as well as prospects of targeting P4-ATPases for anti-cancer treatment.

摘要翻译： 

癌细胞的生存适应能力极为显著。其最显著特性之一是通过改变脂质代谢及由此导致的细胞膜组成异常，来阻止免疫系统反应并抵抗化疗。正常动物细胞质膜中的磷脂分布具有明显的不对称性。脂质翻转酶是调控膜不对称性的酶家族，其中主要类别为IV型P型ATP酶（P4-ATP酶）。翻转酶功能改变会导致膜组织结构变化。对于某些脂质（如磷脂酰丝氨酸），这种变化极为显著，已被视为癌症生物标志物。本综述将系统分析并讨论近期发表的研究成果，重点阐述P4-ATP酶在多种癌症发生发展中的作用机制，以及靶向P4-ATP酶进行抗癌治疗的前景。

原文链接：

Type IV P-Type ATPases: Recent Updates in Cancer Development, Progression, and Treatment