文章：

睡眠时长与压力水平对胃癌风险的影响：基于胃癌汇集（StoP）项目中病例对照研究的汇总分析

Sleep Duration and Stress Level in the Risk of Gastric Cancer: A Pooled Analysis of Case-Control Studies in the Stomach Cancer Pooling (StoP) Project

原文发布日期：29 August 2023

DOI: 10.3390/cancers15174319

类型: Article

开放获取: 是

英文摘要：

The association between sleep and stress and cancer is underinvestigated. We evaluated these factors in association with gastric cancer (GC). Five case-control studies from the Stomach Cancer Pooling (StoP) Project were included. We calculated the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for sleep duration and stress level in association with GC through multiple logistic regression models adjusted for several lifestyle factors. The analysis included 1293 cases and 4439 controls, 215 cardia and 919 noncardia GC, and 353 diffuse and 619 intestinal types. Sleep duration of ≥9 h was associated with GC (OR =1.57, 95% CI = 1.23–2.00) compared to 8 h. This was confirmed when stratifying by subsite (noncardia OR = 1.59, 95% CI = 1.22–2.08, and cardia OR = 1.63, 95% CI = 0.97–2.72) and histological type (diffuse OR = 1.65, 95% CI = 1.14–2.40 and intestinal OR = 1.24, 95% CI = 0.91–1.67). Stress was associated with GC (OR = 1.33, 95% CI = 1.18–1.50, continuous). This relationship was selectively related to noncardia GC (OR = 1.28, 95% 1.12–1.46, continuous). The risk of diffuse (OR = 1.32, 95% CI = 1.11–1.58) and intestinal type (OR = 1.23, 95% CI = 1.07–1.42) were higher when stress was reported. Results for the association between increasing level of stress and GC were heterogeneous by smoking and socioeconomic status (pfor heterogeneity = 0.02 and <0.001, respectively). In conclusion, long sleep duration (≥9 h) was associated with GC and its subtype categories. Stress linearly increased the risk of GC and was related to noncardia GC.

摘要翻译： 

睡眠与压力同癌症的关联性研究尚不充分。本研究基于胃癌汇集项目中的五项病例对照研究，评估了这些因素与胃癌的关联。通过校正多种生活方式因素的多重逻辑回归模型，我们计算了睡眠时长和压力水平与胃癌关联的比值比及其95%置信区间。研究共纳入1293例胃癌患者和4439例对照，其中贲门癌215例、非贲门癌919例，弥漫型353例、肠型619例。与每日睡眠8小时相比，睡眠时长≥9小时与胃癌风险升高相关（OR=1.57，95% CI=1.23-2.00）。按解剖亚位点分层分析显示：非贲门癌（OR=1.59，95% CI=1.22-2.08）与贲门癌（OR=1.63，95% CI=0.97-2.72）均呈现相似趋势；按组织学类型分层显示：弥漫型（OR=1.65，95% CI=1.14-2.40）与肠型（OR=1.24，95% CI=0.91-1.67）亦存在关联。压力水平与胃癌风险呈连续正相关（OR=1.33，95% CI=1.18-1.50），该关联主要体现于非贲门癌（OR=1.28，95% CI=1.12-1.46）。压力暴露同时增加弥漫型（OR=1.32，95% CI=1.11-1.58）与肠型胃癌风险（OR=1.23，95% CI=1.07-1.42）。压力水平与胃癌的关联强度在吸烟人群与非吸烟人群（异质性p=0.02）、不同社会经济地位人群（异质性p<0.001）中存在显著差异。结论：长睡眠时长（≥9小时）与胃癌及其亚型风险相关；压力水平与胃癌风险呈线性正相关，且与非贲门胃癌存在特异性关联。

原文链接：

Sleep Duration and Stress Level in the Risk of Gastric Cancer: A Pooled Analysis of Case-Control Studies in the Stomach Cancer Pooling (StoP) Project