文章：

高温与高温腹腔内化学灌注对腹膜及肿瘤免疫微环境的影响

Effects of Hyperthermia and Hyperthermic Intraperitoneal Chemoperfusion on the Peritoneal and Tumor Immune Contexture

原文发布日期：29 August 2023

DOI: 10.3390/cancers15174314

类型: Article

开放获取: 是

英文摘要：

Hyperthermia combined with intraperitoneal (IP) drug delivery is increasingly used in the treatment of peritoneal metastases (PM). Hyperthermia enhances tumor perfusion and increases drug penetration after IP delivery. The peritoneum is increasingly recognized as an immune-privileged organ with its own distinct immune microenvironment. Here, we review the immune landscape of the healthy peritoneal cavity and immune contexture of peritoneal metastases. Next, we review the potential benefits and unwanted tumor-promoting effects of hyperthermia and the associated heat shock response on the tumor immune microenvironment. We highlight the potential modulating effect of hyperthermia on the biomechanical properties of tumor tissue and the consequences for immune cell infiltration. Data from translational and clinical studies are reviewed. We conclude that (mild) hyperthermia and HIPEC have the potential to enhance antitumor immunity, but detailed further studies are required to distinguish beneficial from tumor-promoting effects.

摘要翻译： 

腹腔热灌注化疗联合腹腔内给药在腹膜转移瘤治疗中的应用日益广泛。热疗能够增强肿瘤灌注并提高腹腔给药后的药物渗透性。腹膜作为一种具有独特免疫微环境的免疫豁免器官，其重要性逐渐被认识。本文首先综述健康腹腔的免疫景观及腹膜转移瘤的免疫微环境特征，继而探讨热疗及其诱导的热休克反应对肿瘤免疫微环境的潜在益处与可能存在的促瘤效应。特别聚焦热疗对肿瘤组织生物力学特性的调节作用及其对免疫细胞浸润的影响机制，并对相关转化研究与临床数据进行系统评述。结论表明，（温和）热疗与腹腔热灌注化疗具有增强抗肿瘤免疫的潜力，但需通过深入研究明确其有益效应与促瘤作用的界限。

原文链接：

Effects of Hyperthermia and Hyperthermic Intraperitoneal Chemoperfusion on the Peritoneal and Tumor Immune Contexture