Colorectal cancer is one of the most common lifestyle-related types of cancer. The exact pathophysiologic mechanism in the relation between (visceral) adipose tissue, systemic inflammation and colorectal cancer remains unknown. This study aimed to assess the association of lifestyle with markers of systemic inflammation at the time of diagnosis in stage I-III colorectal cancer patients. Patients (n= 298) with stage I-III colorectal cancer from three Dutch hospitals were included at diagnosis. Several lifestyle-related variables (MUST nutritional status score, WCRF/AICR healthy lifestyle score, active smoking, alcohol consumption and BMI) and inflammatory markers (plasma levels of IL-6, IL-8, IL-10, TNFα and ‘high sensitive’ hsCRP) were measured at the time of diagnosis. Confounder-adjusted multivariable linear regression models were used to analyse how the lifestyle variables were associated with the inflammatory markers. Statistically significant associations were found between a better WCRF/AICR lifestyle score and lower levels of IL-6 and hsCRP. A medium and high risk of malnutrition according to the MUST score was associated with elevated levels of both IL-8 and hsCRP. An overall unhealthier lifestyle indicated by a lower WCRF/AICR lifestyle score and a higher risk of malnutrition according to the MUST score at the time of diagnosis was associated with elevated levels of inflammatory markers. These findings can contribute to formulating lifestyle advice to improve treatment outcomes and prognosis in patients having CRC in the future.
结直肠癌是最常见的生活方式相关癌症之一。内脏脂肪组织、全身性炎症与结直肠癌之间的确切病理生理机制尚不明确。本研究旨在评估Ⅰ-Ⅲ期结直肠癌患者确诊时生活方式与全身炎症标志物的关联。研究纳入来自荷兰三家医院的298例初诊Ⅰ-Ⅲ期结直肠癌患者，在确诊时同步测量多项生活方式相关变量（MUST营养状况评分、WCRF/AICR健康生活方式评分、主动吸烟、饮酒及体重指数）及炎症标志物（血浆IL-6、IL-8、IL-10、TNFα和高敏C反应蛋白水平）。采用混杂因素校正的多变量线性回归模型分析生活方式变量与炎症标志物的关联。结果显示：较高的WCRF/AICR生活方式评分与较低的IL-6及hsCRP水平存在统计学显著关联；根据MUST评分判定的中高危营养不良风险与IL-8及hsCRP水平升高相关。确诊时较低的WCRF/AICR生活方式评分和较高的MUST营养不良风险所提示的整体不健康生活方式，与炎症标志物水平升高存在关联。这些发现可为制定改善结直肠癌患者治疗结局及预后的生活方式干预方案提供依据。
肿瘤(癌症)患者之家