文章：

肠道微生物组与癌症治疗不良反应发生及进展的关联性研究

The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects

原文发布日期：28 August 2023

DOI: 10.3390/cancers15174301

类型: Article

开放获取: 是

英文摘要：

Adverse effects are a common consequence of cytotoxic cancer treatments. Over the last two decades there have been significant advances in exploring the relationship between the gut microbiome and these adverse effects. Changes in the gut microbiome were shown in multiple clinical studies to be associated with the development of acute gastrointestinal adverse effects, including diarrhoea and mucositis. However, more recent studies showed that changes in the gut microbiome may also be associated with the long-term development of psychoneurological changes, cancer cachexia, and fatigue. Therefore, the aim of this review was to examine the literature to identify potential contributions and associations of the gut microbiome with the wide range of adverse effects from cytotoxic cancer treatments.

摘要翻译： 

细胞毒性癌症治疗常伴随不良反应。近二十年来，关于肠道微生物组与这些不良反应之间关系的研究取得了显著进展。多项临床研究表明，肠道微生物组的变化与急性胃肠道不良反应（包括腹泻和黏膜炎）的发生有关。然而，最新研究显示，肠道微生物组的变化还可能与长期心理神经变化、癌症恶病质及疲劳的发展有关。因此，本综述旨在通过文献分析，探讨肠道微生物组在细胞毒性癌症治疗引发的多种不良反应中的潜在作用及其关联性。

原文链接：

The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects