文章：

青少年及年轻成人群体中的质子治疗

Proton Therapy in the Adolescent and Young Adult Population

原文发布日期：25 August 2023

DOI: 10.3390/cancers15174269

类型: Article

开放获取: 是

英文摘要：

Background: Adolescent and young adult cancer patients are at high risk of developing radiation-associated side effects after treatment. Proton beam radiation therapy might reduce the risk of these side effects for this population without compromising treatment efficacy. Methods: We review the current literature describing the utility of proton beam radiation therapy in the treatment of central nervous system tumors, sarcomas, breast cancer and Hodgkin lymphoma for the adolescent and young adult cancer population. Results: Proton beam radiation therapy has utility for the treatment of certain cancers in the young adult population. Preliminary data suggest reduced radiation dose to normal tissues, which might reduce radiation-associated toxicities. Research is ongoing to further establish the role of proton therapy in this population. Conclusion: This report highlights the potential utility of proton beam radiation for certain adolescent young adult cancers, especially with reducing radiation doses to organs at risk and thereby potentially lowering risks of certain treatment-associated toxicities.

摘要翻译： 

背景：青少年与年轻成人癌症患者在治疗后具有较高的放射相关副作用风险。质子束放射治疗可能在不影响疗效的前提下，降低该人群的副作用风险。方法：本文综述了当前关于质子束放射治疗在青少年与年轻成人中枢神经系统肿瘤、肉瘤、乳腺癌及霍奇金淋巴瘤治疗中应用的相关文献。结果：质子束放射治疗在年轻成人特定癌症治疗中具有应用价值。初步数据显示其对正常组织的辐射剂量有所降低，这可能减少放射相关毒性。目前研究仍在持续进行，以进一步明确质子治疗在该人群中的作用。结论：本报告强调了质子束放射治疗在某些青少年与年轻成人癌症中的潜在应用价值，特别是在降低危及器官的辐射剂量方面，从而可能降低特定治疗相关毒性的风险。

原文链接：

Proton Therapy in the Adolescent and Young Adult Population