Meningiomas have the highest incidence among brain tumors. In contrast to benign tumors that constitute the majority of this tumor entity, the treatment of aggressive meningiomas (WHO Grade 2 and 3) is more challenging, requiring gross total removal of the tumor and the affected dura and adjuvant radiotherapy. Sometimes the location and/or the configuration of the tumor do not favor radical surgical resection without endangering the patient’s clinical condition after surgery and pharmacological therapy has, until now, not been proven to be a reliable alternative. Discussion: In this narrative review, we discuss the current literature with respect to the management of meningiomas, discussing the importance of the grade of resection in the overall prognosis of the patient and in the planning of adjuvant therapy. Conclusions: According to the location and size of the tumor, radical resection should be taken into consideration. In patients with aggressive meningiomas, adjuvant radiotherapy should be performed after surgery. In cases of skull base meningiomas, a maximal, though safe, resection should take place before adjuvant therapy. An interdisciplinary approach is beneficial for patients with primary or recurrent meningioma.
脑膜瘤在脑肿瘤中发病率最高。与构成该肿瘤实体大多数的良性肿瘤相比，侵袭性脑膜瘤（WHO 2级和3级）的治疗更具挑战性，需要将肿瘤及受累硬脑膜完全切除并辅以放射治疗。有时肿瘤的位置和/或形态不利于进行根治性手术切除，否则可能危及患者术后临床状况，而药物治疗至今尚未被证明是可靠的替代方案。讨论：在本篇叙述性综述中，我们讨论了当前关于脑膜瘤治疗的文献，探讨了切除程度对患者总体预后及辅助治疗计划的重要性。结论：根据肿瘤的位置和大小，应考虑进行根治性切除。对于侵袭性脑膜瘤患者，术后应进行辅助放射治疗。对于颅底脑膜瘤病例，在辅助治疗前应进行最大程度的安全切除。多学科协作方法对原发性或复发性脑膜瘤患者有益。
Interdisciplinary Therapeutic Approaches to Atypical and Malignant Meningiomas
肿瘤(癌症)患者之家