文章：

含β-转导蛋白重复序列蛋白作为抗癌靶点研究

Beta-Transducin Repeats-Containing Proteins as an Anticancer Target

原文发布日期：24 August 2023

DOI: 10.3390/cancers15174248

类型: Article

开放获取: 是

英文摘要：

Beta-transducin repeat-containing proteins (β-TrCPs) are E3-ubiquitin-ligase-recognizing substrates and regulate proteasomal degradation. The degradation of β-TrCPs’ substrates is tightly controlled by various external and internal signaling and confers diverse cellular processes, including cell cycle progression, apoptosis, and DNA damage response. In addition, β-TrCPs function to regulate transcriptional activity and stabilize a set of substrates by distinct mechanisms. Despite the association of β-TrCPs with tumorigenesis and tumor progression, studies on the mechanisms of the regulation of β-TrCPs’ activity have been limited. In this review, we studied publications on the regulation of β-TrCPs themselves and analyzed the knowledge gaps to understand and modulate β-TrCPs’ activity in the future.

摘要翻译： 

β-转导重复序列包含蛋白（β-TrCPs）作为识别底物的E3泛素连接酶，参与调控蛋白酶体降解过程。β-TrCPs底物的降解受到多种内外信号通路的精密调控，并影响细胞周期进程、细胞凋亡及DNA损伤应答等多种细胞生物学过程。此外，β-TrCPs还能通过不同机制调控转录活性并稳定特定底物。尽管β-TrCPs与肿瘤发生发展密切相关，目前对其活性调控机制的研究仍较为有限。本综述通过系统分析β-TrCPs自身调控的相关文献，梳理现有认知空白，为未来深入解析和调控β-TrCPs活性提供理论依据。

原文链接：

Beta-Transducin Repeats-Containing Proteins as an Anticancer Target