The impact of age on various aspects of gastric cancer (GC) remains controversial. Clarifying this issue can improve our understanding of the disease, refine risk stratification models, and aid in personalized therapeutic approaches. This study aimed to evaluate the influence of age at diagnosis on the clinicopathological features, prognosis, and management of a specific cohort of Spanish patients with resected GC. The study encompassed 315 patients treated at a single tertiary hospital in Spain, divided into two age-based subgroups: ≤65 years and >65 years. The mean and median ages at diagnosis were 72 and 76 years. Most tumors were diagnosed at pT3 stage (49.2%), and 59.6% of patients had lymph node metastases. 21.3% of cases were diagnosed with GC at age ≤ 65 years. Younger patients showed a significantly higher prevalence of flat, diffuse, high-grade tumors, signet-ring cells, perineural infiltration, D2 lymphadenectomies, and adjuvant therapy. They also exhibited a higher rate of recurrences, but had a significantly longer follow-up. Kaplan-Meier curves indicated no significant prognostic differences based on age. Finally, age did not independently predict overall survival or disease-free survival. Our results suggest that younger patients may require more aggressive treatment due to adverse clinicopathologic features, but the lack of prognostic differences among age groups in our cohort indicates the need for further investigation into the complex interplay between age, clinicopathologic factors, and long-term outcomes in GC.
年龄对胃癌各方面的影响仍存争议。厘清这一问题有助于深化对疾病的认识、完善风险分层模型，并推动个体化治疗策略的发展。本研究旨在评估诊断年龄对西班牙特定胃癌切除患者队列的临床病理特征、预后及治疗管理的影响。研究纳入西班牙某三级医院收治的315例患者，按年龄分为≤65岁和>65岁两个亚组。诊断时的平均年龄和中位年龄分别为72岁和76岁。多数肿瘤确诊时为pT3分期（49.2%），59.6%的患者存在淋巴结转移。21.3%的病例在≤65岁时确诊胃癌。年轻患者中平坦型、弥漫型、高级别肿瘤、印戒细胞、神经浸润、D2淋巴结清扫及辅助治疗的比例显著更高。该群体复发率更高，但随访时间显著更长。Kaplan-Meier曲线显示年龄未导致显著预后差异。最终，年龄并非总体生存期或无病生存期的独立预测因素。研究结果表明，年轻患者因不良临床病理特征可能需要更积极的治疗，但本队列中年龄组间缺乏预后差异，提示需进一步探究年龄、临床病理因素与胃癌长期结局之间复杂的相互作用。
肿瘤(癌症)患者之家