文章：

多溴联苯醚（PBDEs）与人类健康：对代谢、糖尿病及癌症的影响

Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer

原文发布日期：24 August 2023

DOI: 10.3390/cancers15174237

类型: Article

开放获取: 是

英文摘要：

There is increasing evidence of the role of endocrine disruptors (EDs) derived from commonly employed compounds for manufacturing and processing in altering hormonal signaling and function. Due to their prolonged half-life and persistence, EDs can usually be found not only in industrial products but also in households and in the environment, creating the premises for long-lasting exposure. Polybrominated diphenyl ethers (PBDEs) are common EDs used in industrial products such as flame retardants, and recent studies are increasingly showing that they may interfere with both metabolic and oncogenic pathways. In this article, a multidisciplinary panel of experts of the Italian Association of Medical Diabetologists (AMD), the Italian Society of Diabetology (SID), the Italian Association of Medical Oncology (AIOM), the Italian Society of Endocrinology (SIE) and the Italian Society of Pharmacology (SIF) provides a review on the potential role of PBDEs in human health and disease, exploring both molecular and clinical aspects and focusing on metabolic and oncogenic pathways.

摘要翻译： 

越来越多的证据表明，源自制造和加工常用化合物的内分泌干扰物（EDs）在改变激素信号传导和功能方面发挥着重要作用。由于其较长的半衰期和持久性，内分泌干扰物不仅常见于工业产品中，也广泛存在于家庭和环境中，为长期暴露创造了条件。多溴联苯醚（PBDEs）是工业产品（如阻燃剂）中常用的内分泌干扰物，近期研究日益显示其可能干扰代谢通路和致癌通路。本文由意大利医学糖尿病学家协会（AMD）、意大利糖尿病学会（SID）、意大利医学肿瘤学协会（AIOM）、意大利内分泌学会（SIE）及意大利药理学学会（SIF）的多学科专家团队共同撰写，综述了多溴联苯醚对人类健康和疾病的潜在影响，从分子机制到临床表现进行探讨，并重点关注代谢通路与致癌通路。

原文链接：

Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer