Gliomas, which arise from glial cells in the brain, remain a significant challenge due to their location and resistance to traditional treatments. Despite research efforts and advancements in healthcare, the incidence of gliomas has risen dramatically over the past two decades. The dysregulation of microRNAs (miRNAs) has prompted the creation of therapeutic agents that specially target them. However, it has been reported that they are involved in complex signaling pathways that contribute to the loss of expression of tumor suppressor genes and the upregulation of the expression of oncogenes. In addition, numerous miRNAs promote the development, progression, and recurrence of gliomas by targeting crucial proteins and enzymes involved in metabolic pathways such as glycolysis and oxidative phosphorylation. However, the complex interplay among these pathways along with other obstacles hinders the ability to apply miRNA targeting in clinical practice. This highlights the importance of identifying specific miRNAs to be targeted for therapy and having a complete understanding of the diverse pathways they are involved in. Therefore, the aim of this review is to provide an overview of the role of miRNAs in the progression and prognosis of gliomas, emphasizing the different pathways involved and identifying potential therapeutic targets.
胶质瘤起源于大脑中的胶质细胞，由于其位置特殊且对传统治疗方法具有抵抗性，目前仍是重大治疗挑战。尽管医疗研究不断深入并取得进展，但过去二十年间胶质瘤的发病率急剧上升。微小RNA（miRNA）的失调促使了特异性靶向治疗药物的研发。然而研究表明，这些miRNA通过参与复杂的信号通路，导致抑癌基因表达缺失和癌基因表达上调。此外，大量miRNA通过靶向糖酵解和氧化磷酸化等代谢途径中的关键蛋白和酶，促进胶质瘤的发生、发展和复发。但这些通路间复杂的相互作用及其他障碍，阻碍了miRNA靶向治疗在临床实践中的应用。这凸显了明确治疗靶向的特异性miRNA，并全面理解其参与的多重通路的重要性。因此，本综述旨在概述miRNA在胶质瘤进展和预后中的作用，重点阐明其涉及的不同通路，并识别潜在的治疗靶点。
Exploring the Role of microRNAs in Glioma Progression, Prognosis, and Therapeutic Strategies
肿瘤(癌症)患者之家