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文章:

吲哚菁绿荧光成像在机器人辅助肝切除术中肿瘤定位的应用

Application of Indocyanine Green Fluorescence Imaging for Tumor Localization during Robot-Assisted Hepatectomy

原文发布日期:22 August 2023

DOI: 10.3390/cancers15174205

类型: Article

开放获取: 是

 

英文摘要:

The efficacy of indocyanine green (ICG) fluorescence imaging for visualizing hepatic tumors in robot-assisted hepatectomy (RAH) should be validated. This study included 30 consecutive patients with 33 collective tumors who underwent RAH. ICG was administered at a dose of 0.5 mg/kg before surgery. ICG fluorescence imaging was performed intraoperatively. In total, 28 patients with a combined total of 31 tumors underwent ICG fluorescence imaging. Further, 26 (84%) tumors were identified on hepatic surfaces prior to hepatic transection. The fluorescence signals of eight tumors were detected on hepatic raw surfaces during parenchymal dissection, thereby enabling surgeons to adjust the transection planes to ensure appropriate surgical margins. One patient with intrahepatic cholangiocarcinoma tested positive for cancer cells at the dissected stump of the bile duct. However, in all patients in whom ICG fluorescence imaging was used, negative surgical margins were achieved at the site of the dissected hepatic parenchyma. On the other hand, one of two patients with ICG contraindications had a positive surgical margin surrounding the dissected hepatic parenchyma. The median operative time and volume of blood loss were 259 (range: 124–594) min and 150 (range: 1–1150) mL, respectively. ICG fluorescence imaging facilitates the easy identification of hepatic tumors, even in RAH. Hence, it can be useful for confirming appropriate surgical margins.

 

摘要翻译: 

吲哚菁绿(ICG)荧光成像在机器人辅助肝切除术(RAH)中用于显示肝肿瘤的效果需进一步验证。本研究连续纳入30例共33个肿瘤接受RAH的患者。术前按0.5 mg/kg剂量静脉注射ICG,术中实施ICG荧光成像。最终共有28例患者的31个肿瘤完成ICG荧光成像检查,其中26个(84%)肿瘤在肝实质离断前于肝脏表面被成功识别。在肝实质离断过程中,另有8个肿瘤在肝脏创面检测到荧光信号,从而使外科医生能够调整离断平面以确保足够的手术切缘。1例肝内胆管癌患者的胆管离断残端检测到癌细胞阳性。然而,在所有应用ICG荧光成像的患者中,肝实质离断部位均实现了阴性手术切缘。另一方面,2例存在ICG禁忌症的患者中,有1例在肝实质离断区域出现阳性手术切缘。中位手术时间和术中失血量分别为259(范围:124-594)分钟和150(范围:1-1150)毫升。ICG荧光成像技术即使在RAH中也能便捷地识别肝肿瘤,因此可用于确认适宜的手术切缘。

 

原文链接:

Application of Indocyanine Green Fluorescence Imaging for Tumor Localization during Robot-Assisted Hepatectomy

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