Mangiferin (MGF), a xanthone derived fromMangifera indicaL., initially employed as a nutraceutical, is now being explored extensively for its anticancer potential. Scientists across the globe have explored this bioactive for managing a variety of cancers using validated in vitro and in vivo models. The in vitro anticancer potential of this biomolecule on well-established breast cancer cell lines such as MDA-MB-23, BEAS-2B cells and MCF-7 is closer to many approved synthetic anticancer agents. However, the solubility and bioavailability of this xanthone are the main challenges, and its oral bioavailability is reported to be less than 2%, and its aqueous solubility is also 0.111 mg/mL. Nano-drug delivery systems have attempted to deliver the drugs at the desired site at a desired rate in desired amounts. Many researchers have explored various nanotechnology-based approaches to provide effective and safe delivery of mangiferin for cancer therapy. Nanoparticles were used as carriers to encapsulate mangiferin, protecting it from degradation and facilitating its delivery to cancer cells. They have attempted to enhance the bioavailability, safety and efficacy of this very bioactive using drug delivery approaches. The present review focuses on the origin and structure elucidation of mangiferin and its derivatives and the benefits of this bioactive. The review also offers insight into the delivery-related challenges of mangiferin and its applications in nanosized forms against cancer. The use of a relatively new deep-learning approach to solve the pharmacokinetic issues of this bioactive has also been discussed. The review also critically analyzes the future hope for mangiferin as a therapeutic agent for cancer management.
芒果苷（MGF）是一种从芒果中提取的呫吨酮类化合物，最初作为营养保健品使用，目前其抗癌潜力正受到广泛探索。全球科学家已通过验证的体外和体内模型研究了这种生物活性物质在多种癌症治疗中的应用。该生物分子在MDA-MB-23、BEAS-2B细胞和MCF-7等成熟乳腺癌细胞系上展现的体外抗癌潜力，已接近多种已获批的合成抗癌药物。然而，该呫吨酮的溶解度和生物利用度是主要挑战，据报道其口服生物利用度低于2%，水溶性也仅为0.111 mg/mL。纳米药物递送系统致力于以精准的速率和剂量将药物输送至目标部位。许多研究者探索了基于纳米技术的多种方法，旨在实现芒果苷在癌症治疗中的高效安全递送。纳米颗粒作为载体包裹芒果苷，可保护其免于降解并促进其向癌细胞的输送。通过药物递送策略，研究者试图提升这种高活性物质的生物利用度、安全性和疗效。本综述聚焦于芒果苷及其衍生物的来源与结构解析，以及该生物活性物质的优势，同时深入探讨了芒果苷在递送过程中面临的挑战及其纳米剂型在抗癌领域的应用。文中还讨论了运用新兴的深度学习方法解决该生物活性物质药代动力学问题的可能性，并对芒果苷作为癌症治疗药物的未来前景进行了批判性分析。
肿瘤(癌症)患者之家