文章：

黑色素瘤免疫治疗：最新进展与未来方向

Immunotherapy in Melanoma: Recent Advancements and Future Directions

原文发布日期：19 August 2023

DOI: 10.3390/cancers15164176

类型: Article

开放获取: 是

英文摘要：

Immune checkpoint inhibition has fundamentally altered the treatment paradigm of resectable and unresectable melanoma, resulting in dramatic improvements in patient outcomes. With these advances, the five-year overall survival in patients with newly diagnosed unresectable disease has eclipsed 50%. Ongoing research is focused on improving outcomes further, with a considerable emphasis on preventing de novo and acquired resistance and personalizing therapeutic options. Here, we review the ongoing advancements in the treatment of malignant melanoma, focusing on novel combination strategies that aim to build upon the successes of the last decade.

摘要翻译： 

免疫检查点抑制剂的应用从根本上改变了可切除与不可切除黑色素瘤的治疗模式，显著改善了患者预后。随着这些进展，新诊断不可切除黑色素瘤患者的五年总生存率已突破50%。当前研究重点在于进一步提升疗效，特别关注预防原发性和获得性耐药，以及实现治疗方案的个体化。本文综述恶性黑色素瘤治疗领域的最新进展，重点关注旨在延续过去十年成功经验的新型联合治疗策略。

原文链接：

Immunotherapy in Melanoma: Recent Advancements and Future Directions