Purpose: To assess the recurrence and birth rates among patients with non-epithelial ovarian cancer. Methods: The study included 146 patients with germ cell (GCT, n = 84) and sex cord-stromal tumors (SCST, n = 62), who underwent fertility-sparing surgery. Adjuvant chemotherapy was administered to 86 (58.9%) patients. Most cases (133 out of 146) were staged FIGO I. Results: The 5- and 10-year disease-free survival rates were 91% and 83%, respectively. The recurrence risk was not associated with tumor histology, stage or age. Twenty-four months after the treatment, the rate of recurrence was higher than the rate of childbearing. The childbearing rates kept rising after the treatment and exceeded the rate of recurrence after 2 years. The cumulative incidence rates of birth 36, 60 and 120 months after treatment were 13.24%, 20.75%, and 42.37%, respectively. Chemotherapy was not related to childbearing. The patients’ age was related to the chance of childbearing. Conclusions: The prognoses of GCT and SCST are similar. Close follow-ups along with contraception should be offered to women during the first two years after treatment due to the increased risk of recurrence. After this period, relapses are rare and women can safely become pregnant.
目的：评估非上皮性卵巢癌患者的复发率与生育率。方法：本研究纳入了146例接受保留生育功能手术的生殖细胞肿瘤（GCT，n=84）和性索间质肿瘤（SCST，n=62）患者，其中86例（58.9%）接受了辅助化疗。大多数病例（146例中的133例）为FIGO I期。结果：5年和10年无病生存率分别为91%和83%。复发风险与肿瘤组织学类型、分期或年龄无关。治疗后24个月内，复发率高于生育率。治疗后生育率持续上升，并在2年后超过复发率。治疗后36、60和120个月的累计生育率分别为13.24%、20.75%和42.37%。化疗与生育无关，患者年龄与生育机会相关。结论：GCT与SCST的预后相似。由于治疗后前两年复发风险较高，应为患者提供密切随访并建议避孕。此后复发罕见，患者可安全妊娠。
Obstetric Results after Fertility-Sparing Management of Non-Epithelial Ovarian Cancer
肿瘤(癌症)患者之家