文章：

癌症中的长链非编码RNA ANRIL

The Long Non-Coding RNA ANRIL in Cancers

原文发布日期：17 August 2023

DOI: 10.3390/cancers15164160

类型: Article

开放获取: 是

英文摘要：

ANRIL (Antisense Noncoding RNA in the INK4 Locus), a long non-coding RNA encoded in the human chromosome9p21region, is a critical factor for regulating gene expression by interacting with multiple proteins and miRNAs. It has been found to play important roles in various cellular processes, including cell cycle control and proliferation. Dysregulation of ANRIL has been associated with several diseases like cancers and cardiovascular diseases, for instance. Understanding the oncogenic role of ANRIL and its potential as a diagnostic and prognostic biomarker in cancer is crucial. This review provides insights into the regulatory mechanisms and oncogenic significance of the9p21locus and ANRIL in cancer.

摘要翻译： 

ANRIL（INK4基因座反义非编码RNA）是一种位于人类染色体9p21区域的长链非编码RNA，通过与多种蛋白质及miRNA相互作用，成为调控基因表达的关键因子。研究发现，ANRIL在细胞周期调控、增殖等多种细胞过程中发挥重要作用。其表达失调与癌症、心血管疾病等多种疾病密切相关。深入理解ANRIL的致癌作用及其作为癌症诊断与预后生物标志物的潜力至关重要。本综述系统阐述了9p21基因座及ANRIL在癌症中的调控机制与致癌意义。

原文链接：

The Long Non-Coding RNA ANRIL in Cancers