文章：

炎症性肠病与结直肠癌：流行病学、病因学、监测与管理

Inflammatory Bowel Disease and Colorectal Cancer: Epidemiology, Etiology, Surveillance, and Management

原文发布日期：17 August 2023

DOI: 10.3390/cancers15164154

类型: Article

开放获取: 是

英文摘要：

Patients with inflammatory bowel diseases (IBDs), such as ulcerative colitis and Crohn’s disease, have an increased risk of developing colorectal cancer (CRC). Although advancements in endoscopic imaging techniques, integrated surveillance programs, and improved medical therapies have contributed to a decreased incidence of CRC in patients with IBD, the rate of CRC remains higher in patients with IBD than in individuals without chronic colitis. Patients with IBD-related CRCs exhibit a poorer prognosis than those with sporadic CRCs, owing to their aggressive histological characteristics and lower curative resection rate. In this review, we present an updated overview of the epidemiology, etiology, risk factors, surveillance strategies, treatment recommendations, and prognosis of IBD-related CRCs.

摘要翻译： 

炎症性肠病（如溃疡性结肠炎和克罗恩病）患者罹患结直肠癌的风险显著增加。尽管内镜成像技术的进步、系统性监测项目的实施以及药物治疗方案的优化已促使炎症性肠病患者结直肠癌发病率有所下降，但其患病率仍高于非慢性结肠炎人群。由于具有侵袭性组织学特征及根治性切除率较低等特点，炎症性肠病相关结直肠癌患者的预后较散发性结直肠癌患者更差。本文综述将围绕炎症性肠病相关结直肠癌的流行病学特征、病因机制、危险因素、监测策略、治疗建议及预后评估等方面提供最新研究进展。

原文链接：

Inflammatory Bowel Disease and Colorectal Cancer: Epidemiology, Etiology, Surveillance, and Management