文章：

介电谱显示脑膜瘤组织与脑白质及灰质之间存在介电常数差异——一种潜在的脑膜瘤鉴别物理生物标志物

Dielectric Spectroscopy Shows a Permittivity Contrast between Meningioma Tissue and Brain White and Gray Matter—A Potential Physical Biomarker for Meningioma Discrimination

原文发布日期：17 August 2023

DOI: 10.3390/cancers15164153

类型: Article

开放获取: 是

英文摘要：

The effectiveness of surgical resection of meningioma, the most common primary CNS tumor, depends on the capability to intraoperatively discriminate between the meningioma tissue and the surrounding brain white and gray matter tissues. Aiming to find a potential biomarker based on tissue permittivity, dielectric spectroscopy of meningioma, white matter, and gray matter ex vivo tissues was performed using the open-ended coaxial probe method in the microwave frequency range from 0.5 to 18 GHz. The averages and the 95% confidence intervals of the measured permittivity for each tissue were compared. The results showed the absence of overlap between the 95% confidence intervals for meningioma tissue and for brain white and gray matter, indicating a significant difference in average permittivity (p≤ 0.05) throughout almost the entire measured frequency range, with the most pronounced contrast found between 2 GHz and 5 GHz. The discovered contrast is relevant as a potential physical biomarker to discriminate meningioma tissue from the surrounding brain tissues by means of permittivity measurement, e.g., for intraoperative meningioma margin assessment. The permittivity models for each tissue, developed in this study as its byproducts, will allow more accurate electromagnetic modeling of brain tumor and healthy tissues, facilitating the development of new microwave-based medical devices and tools.

摘要翻译： 

脑膜瘤作为最常见的原发性中枢神经系统肿瘤，其手术切除效果取决于术中区分脑膜瘤组织与周围脑白质及灰质组织的能力。为探索基于组织介电常数的潜在生物标志物，本研究采用开放式同轴探头法，在0.5至18 GHz微波频率范围内对离体脑膜瘤、白质和灰质组织进行了介电谱测量。通过比较各组织介电常数的平均值及95%置信区间，结果显示脑膜瘤组织与脑白质、灰质组织的95%置信区间在全测量频段内均无重叠，表明平均介电常数存在显著差异（p≤0.05），其中2 GHz至5 GHz频段的对比度最为显著。这一发现可作为通过介电常数测量（如术中脑膜瘤边缘评估）区分脑膜瘤与周围脑组织的潜在物理标志物。本研究建立的各组织介电常数模型作为衍生成果，将提升脑肿瘤与健康组织电磁建模的精确度，有助于开发新型微波医疗设备与工具。

原文链接：

Dielectric Spectroscopy Shows a Permittivity Contrast between Meningioma Tissue and Brain White and Gray Matter—A Potential Physical Biomarker for Meningioma Discrimination