The tumor stroma, or the microenvironment surrounding solid tumors, can significantly impact the effectiveness of cancer therapies. The tumor microenvironment is characterized by high interstitial pressure, a consequence of leaky vasculature, and dense stroma created by excessive deposition of various macromolecules such as collagen, fibronectin, and hyaluronic acid (HA). In addition, non-cancerous cells such as cancer-associated fibroblasts (CAFs) and the extracellular matrix (ECM) itself can promote tumor growth. In recent years, there has been increased interest in combining standard cancer treatments with stromal-targeting strategies or stromal modulators to improve therapeutic outcomes. Furthermore, the use of nanomedicine, which can improve the delivery and retention of drugs in the tumor, has been proposed to target the stroma. This review focuses on how different stromal components contribute to tumor progression and impede chemotherapeutic delivery. Additionally, this review highlights recent advancements in nanomedicine-based stromal modulation and discusses potential future directions for developing more effective stroma-targeted cancer therapies.
肿瘤基质，即实体瘤周围的微环境，可显著影响癌症治疗的效果。肿瘤微环境的特征表现为高间质压力，这是由血管渗漏以及胶原蛋白、纤连蛋白和透明质酸等多种大分子过度沉积形成的致密基质所致。此外，癌症相关成纤维细胞等非癌细胞以及细胞外基质本身均可促进肿瘤生长。近年来，将标准癌症治疗与基质靶向策略或基质调节剂相结合以提高治疗效果的研究日益受到关注。同时，能够改善药物在肿瘤内递送和滞留的纳米药物也被提出用于靶向基质。本综述重点探讨不同基质成分如何促进肿瘤进展并阻碍化疗药物递送，同时概述基于纳米药物的基质调控最新进展，并讨论未来开发更有效基质靶向癌症疗法的潜在方向。
肿瘤(癌症)患者之家