The objective of this study was to evaluate the psychometric properties of a new patient-reported outcome instrument intended for use with patients who have undergone brachytherapy for uveal melanoma (PROM-UM). Classical test theory and item response theory were used to evaluate the performance of individual items and domains. A convenience sample of 439 participants who had undergone brachytherapy for uveal melanoma from one of three North American ocular oncology treatment centers were included in this cross-sectional study. Exploratory factor analysis identified three domains which were labelled “Symptom Impairment”, “Worry”, and “Discomfort”. The acceptability of the instrument was supported by little missing data (range = 0.00–1.14%) and low maximum endorsement (range = 0.00–1.82%). Item-total (range = 0.68–0.85) and inter-item (range = 0.74–0.80) correlations indicated acceptable reliability. Discrimination and difficulty were assessed using item response theory. Items in all three domains indicated moderate to very high discrimination (range = 1.00–4.10). Two items in the Symptom Impairment domain were too difficult to measure. Response ranges in the other two domains demonstrated acceptable difficulty. These results from the study indicate that this new patient-reported outcome instrument can be used with patients treated with brachytherapy for uveal melanoma. Providers could use this instrument to help inform post-treatment management.
本研究旨在评估一种新型患者报告结局量表（PROM-UM）的心理测量学特性，该量表专为接受葡萄膜黑色素瘤近距离放射治疗的患者设计。研究采用经典测验理论与项目反应理论对量表各条目及维度的性能进行评估。本横断面研究纳入了来自北美三家眼肿瘤治疗中心的439例接受葡萄膜黑色素瘤近距离放射治疗的患者作为便利样本。探索性因子分析识别出三个维度，分别命名为"症状困扰"、"焦虑情绪"和"不适感受"。量表可接受性得到以下数据支持：缺失数据极少（范围=0.00–1.14%），最高认可度较低（范围=0.00–1.82%）。条目-总分相关（范围=0.68–0.85）与条目间相关（范围=0.74–0.80）表明量表具有可接受的信度。通过项目反应理论评估区分度与难度参数，结果显示三个维度的条目均具有中等至极高区分度（范围=1.00–4.10）。"症状困扰"维度中有两个条目测量难度过高，其余两个维度的反应范围显示出可接受的难度水平。研究结果表明，该新型患者报告结局量表适用于接受近距离放射治疗的葡萄膜黑色素瘤患者。临床工作者可借助该量表为治疗后管理决策提供参考依据。
肿瘤(癌症)患者之家